Hajime Tsuzuki ( 綴喜創, Tsuzuki Hajime), a doctor knowledgeable on the human body, and an acquaintance of Rui's.In the anime television series, he is voiced by Makoto Furukawa. Rui Chihaya ( 千早瑠依, Chihaya Rui), a womanizing playboy, and a close friend of Shion's.In the anime television series, he is voiced by Kazutomi Yamamoto, both in his male and female forms.
After being drugged, his body changes to look like a woman's. Rui does at first not recognize Shion, and falls in love with him at first sight. To teach him a lesson about his womanizing ways, a woman drugs Shion, which alters his body to look like a woman's. Fucked by My Best Friend is a gay romantic comedy manga, which follows Shion Chihara and Rui Chihaya, two close friends and pickup artists.